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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

The long-term safety profile of BPC-157 is still under investigation, as most studies and clinical use have been short-term

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412 Likewise, astrocytes with small cell bodies and less complex processes were identified in Rhesus macaques with a self-injurious behaviour